06 Mar 2023

Improving intestinal health with tributyrin and alpha-monobutyrin

Sustainable and efficient animal production is important in poultry husbandry. However, in commercial flocks, animals are subjected to multiple stress factors such as high stocking densities and suboptimal climate conditions which...

Improving intestinal health with tributyrin and alpha-monobutyrin

intestinal health structure framelcoSustainable and efficient animal production is important in poultry husbandry. However, in commercial flocks, animals are subjected to multiple stress factors such as high stocking densities and suboptimal climate conditions which makes them highly susceptible for pathogens. This results in:

  • decreased growth performance,
  • high mortality rates and
  • a lower profitability.

The use of antibiotics is restricted due to the increasing number of resistant bacteria and therefore other solutions must be found.

A dietary feed supplement which supports intestinal health by stimulating intestinal development, modulating the immune response and reducing the growth of pathogenic bacteria, thereby improving animal performance and production is of high interest.

FRA® Butyrin Hybrid

Butyrate glycerides (butyrin) come in multiple forms of which tributyrin and alpha-monobutyrin are the most potent. Both tributyrin and alpha-monobutyrin derive from the esterification of butyric acid with glycerol. Depending on the reaction time, pressure and temperature, different butyrate glycerides are formed which possesses different properties. As the name implies, tributyrin consists of three molecules of butyric acid which makes it highly concentrated in butyric acid.

Tributyrin is a fat, which under the action of lipase will release butyric acid in the small intestine. Tributyrin has already proven to promote:

In contrast to tributyrin, alpha-monobutyrin contains only one molecule of butyric acid positioned at the first carbon atom of the glycerol backbone. This molecule can interact with the bacteria and control the pathogenic activity.

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Alpha-monobutyrin is also pH-independent, meaning it will not dissociate in the gastro-intestinal tract due to the pH level, in contrast to fatty acids which are pH dependent.

The combined effect of tributyrin and alpha-monobutyrin (FRA® Butyrin Hybrid) on broiler performance, intestinal health and apparent metabolizable energy (AME) was tested at Bangkok Animal Research Center.

materials and methods framelco

Material & Methods

Combination tributyrin & alpha-monobutyrin improves animal performance, production efficiency and economics

After a production cycle of 42 days the broilers in the control group




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