The Connection between Stress and Intestinal Inflammation: How Do Bacteria Benefit from Intestinal inflammation?

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Inflammation is the body’s response to cellular injury and a final stage of the stress process, regardless of its origin or nature (biological, environmental, nutritional, physical, chemical, or psychological).

Stress and inflammation are nonspecific defense mechanisms (innate responses) involving hormones, neuropeptides, immune cells, and molecular mediators that are essential for the survival and healing processes in all living organisms.

During a stressful situation, the hormones (adrenaline and glucocorticoids) prepare all cells in the body to either “fight or fly.”

• If the stress continues, these hormones remain in circulation, keeping the animal in chronic “survival-mode.”
• Under stress, the animal reduces its growth, and a massive oxidative stress response causes chronic inflammation.
• Oxidative stress damages cell and mitochondria membranes and, consequently, compromises cell physiology in all tissues and organs. For these reasons, chronic stress and inflammation are called “secret killers.”

Aside from being in charge of absorption and digestion of water and feed, the gastrointestinal tract harbors a diverse and complex microbial community known as gut microbiota. The intestinal microbiota overpasses the number of somatic cells by ~10:1, and ~300,000 genes versus 23,000 genes in the chicken. Also, the enteric nervous system (the second brain) has over 100 million neurons, more than in the peripheric nervous system.

During chronic stress and intestinal inflammation, vital body energy, which under normal conditions the birds’ use for feed efficiency and growth, is utilized to keep the system in “survival mode.”