10 Nov 2021

Invasion inhibition effects and immunogenicity after vaccination of SPF chicks with a Salmonella Enteritidis live vaccine

Invasion inhibition effects and immunogenicity after vaccination of SPF chicks with a Salmonella Enteritidis live vaccine Meat and eggs from […]

Invasion inhibition effects and immunogenicity after vaccination of SPF chicks with a Salmonella Enteritidis live vaccine

Invasion inhibition effects and immunogenicity after vaccination of SPF chicks with a Salmonella Enteritidis live vaccine

Meat and eggs from chickens infected with Salmonella Enteritidis, Salmonella Typhimurium and Salmonella Infantis are considered to be an important source of Salmonella infections for humans.

In order to control Salmonella infections in chickens, basic biosecurity measures are taken in combination with inactivated or attenuated live vaccines. Apart from an adaptive immune response, some live vaccines also induce innate immune mechanisms that prevent or inhibit systemic invasion with homologous Salmonella serovars.

It is unknown whether these invasion inhibition effects are also directed against heterologous Salmonella serovars.

Cobbcares INT WVEPAH

Furthermore, it is unclear whether the adaptive immune response after vaccination with a Salmonella Enteritidis phage type 4 live vaccine is also directed against other phage types of Salmonella Enteritidis and Typhimurium.

Material and methods

Specific pathogen-free day-old chicks were vaccinated orally with a commercially available ­Salmonella Enteritidis live vaccine. To test the invasion inhibition effect, the animals were challenged orally with a labelled Salmonella Typhimurium or Salmonella Infantis strain 1 day after vaccination. To demonstrate the adaptive immune response against non-phage type 4 Salmonella Enteritidis strains and a monophasic Salmonella Typhimurium strain, the chickens were challenged with Salmonella Enteritidis strains of phage types 1, 8 and 21 and a monophasic Salmonella Typhimurium strain (Definitive Type 193).

Liptosa INT 2022
Cobbcares INT
Ceva Int 2022
WVEPAH

After challenge, the abundance of the challenge strain in liver and cecal tissue was enumerated and compared with a corresponding control group.

Results

Findings showed that the live Salmonella Enteritidis vaccine inhibits systemic invasion after early infection with Salmonella Typhimurium and Salmonella Infantis. Furthermore, adaptive immunity against the tested non-phage type 4 Sal- monella Enteritidis strains and the monophasic Salmonella Typhimurium strain was demonstrated.

Conclusion and clinical

relevance The results of this study demonstrate that vaccination with the Salmonella Enteritidis phage type 4 live vaccine significantly inhibits the invasion of Salmonella Typhimurium and Infantis. Furthermore, an adap- tive immune response was also detected against non-phage type 4 Salmonella Enteritidis strains and a monophasic Salmo- nella Typhimurium strain.

If you want to read the complete scientific study, download the PDF file

Cobbcares INT
WVEPAH
Ceva Int 2022
Liptosa INT 2022
Related to Pathology
Ceva Int 2022
Liptosa INT 2022
Cobbcares INT
WVEPAH

MAGAZINE AVINEWS INTERNATIONAL

Subscribe now to the poultry technical magazine

JOIN OUR POULTRY COMMUNITY

Access the PDF articles
Keep up to date with our newsletters
Receive the magazine for free in digital version

DISCOVER
AgriFM - The Livestock Sector Podcasts in English
agriCalendar - The events calendar of the agricultural worldagriCalendar
agrinewsCampus - Training courses for the livestock sector